Proteins 1 and 2 interact strongly. A significant part of the interaction is between the amino acid side chains shown below.
Assume that a mutation occurs in protein 2 that changes the amino acid shown above to one of the amino acids shown below.

What change should disrupt the interaction between proteins 1 and 2 the most? the least?

A. The most: aspartic acid; the least: leucine

B. The most: lysine; the least: serine

C. The most: Serine; the least: aspartic acid

D. The most: lysine; the least: aspartic acid

E. The most: aspartic acid; the least: serine