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These images are from an 36 year old woman, who
carried the diagnosis of Down's syndrome, with mental retardation and a question of progressive mental decline.
Cerebral calcinosis, calcification of various regions of the brain, is
found in a wide range of disorders, and is often found in normal people.
That is, it can represent a sporadic condition with normal calcium metabolism.
Less common associations are with hypoparathyroidism, pseudo-hypoparathyroidism, Fahr's familial idiopathic cerebral calcificatinon, birth anoxia, carbon monoxide intoxication, lead poisoning, Tuberous Sclerosis, Cockaynes syndrome, postinfectious encephalomyelitis, AIDS, radiation therapy, methotrexate, mitochondrial disease (Kearns-Sayer), and, as in the case shown here, Down's syndrome.
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