Biochemistry at The Biology Project

Carbohydrate Metabolism Regulation Problem Set

Question 5: Enzyme Phosphorylation Induced by Glucagon

The same enzymes that are dephosphorylated by insulin action (namely glycogen synthase, glycogen phosphorylase, the PFK-2/FBPase-2 bifunctional enzyme and pyruvate kinase) are phosphorylated via glucagon and/or epinephrine action. Which kinase is responsible for these phosphorylation events?

A. Protein kinase C
B. Calmodulin-dependent kinase
C. Protein kinase A
This is a very clear example of how glucagon and epinephrine oppose the actions of insulin. Also, the general rule that insulin promotes dephosphorylation, while glucagon promotes phosphorylation via cAMP/protein kinase A, will hold up very well throughout the course.
D. Receptor tyrosine kinase
E. b-ARK

[Problem 5] [Tutorial] [Problem 6]

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