| Tour 1: Next/Previous/Start: This tour will examine the brain of an elderly woman with
Alzheimer's disease. This brain displays many of the commonest
features of the disease: brain shrinkage, or atrophy, and loss of
function, as indicated by hypoperfusion (described in Tour 2). First, look at the prominent
sulci, especially the central sulcus. Some
reduction in brain volume is a part of normal aging, but compare this brain with the normal central sulcus, from a normal 81 year old woman. The abnormal shrinkage seen in this case, while not a finding specific to Alzheimer's disease, is severe and seems to affect some regions more
than others.
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